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Do not take Paxil with any of the following:

  • certain diet drugs like dexfenfluramine, fenfluramine, phentermine
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • medicines similar to paroxetine like fluoxetine, sertraline, citalopram
  • phenothiazines like thioridazine
  • pimozide
  • procarbazine
  • St. John's wort
  • tryptophan

Paxil may also interact with the following:

  • aspirin and aspirin-like drugs
  • cimetidine
  • digoxin
  • fosamprenavir
  • linezolid
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • phenobarbital
  • phenytoin
  • procyclidine
  • ritonavir
  • theophylline

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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